PRODUCT DETAILS

About Colibest Tablet

DROTAVERINE+NIMESULIDE belongs to the group of medicines called muscle relaxants indicated for the relief of painful skeletal muscle spasms. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasms are the involuntary contractions of muscles that can be painful. Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves.

DROTAVERINE+NIMESULIDE is a combination of two drugs: Nimesulide (NSAID) and Drotaverine (Muscle relaxant). Nimesulide works by inhibiting the synthesis of prostaglandins which are responsible for pain and inflammation. Drotaverine acts on the brain and spinal cord centers where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms or stiffness. Together, DROTAVERINE+NIMESULIDE helps in relieving musculoskeletal pain.

Take DROTAVERINE+NIMESULIDE with or without food or as directed by your doctor. Swallow DROTAVERINE+NIMESULIDE as a whole with water, do not crush or chew the tablet. You are advised to take DROTAVERINE+NIMESULIDE for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as nausea, vomiting, diarrhea, dryness in the mouth, and dizziness in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take DROTAVERINE+NIMESULIDE if you are pregnant or breastfeeding unless prescribed by the doctor. DROTAVERINE+NIMESULIDE is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with DROTAVERINE+NIMESULIDE as it could increase the risk of stomach bleeding. DROTAVERINE+NIMESULIDE may cause sleepiness and dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Colibest Tablet

Musculoskeletal pain, muscle spasms

Medicinal Benefits of Colibest Tablet

DROTAVERINE+NIMESULIDE is a combination of two drugs, namely: Nimesulide and Drotaverine. DROTAVERINE+NIMESULIDE is used to relieve pain and stiffness caused by muscle strains and sprains. Nimesulide is an NSAID that inhibits the synthesis of prostaglandins responsible for pain and inflammation. Drotaverine is a muscle relaxant that acts on the brain and spinal cord centers where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms or stiffness. Together, DROTAVERINE+NIMESULIDE helps in relieving pain due to muscle spasms.

Directions for Use

Take DROTAVERINE+NIMESULIDE with or without food or as directed by your doctor. Swallow DROTAVERINE+NIMESULIDE as a whole with a glass of water, do not chew or break the tablet. Based on your medical condition, your doctor will decide how long you need to take DROTAVERINE+NIMESULIDE.

Side Effects of Colibest Tablet

• Nausea
• Vomiting
• Diarrhea
• Dryness in mouth
• Feeling thirsty
• Dizziness
• Increased liver enzymes

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take DROTAVERINE+NIMESULIDE if you are allergic to any of its contents, if you have bled into the brain, impaired liver function, blood clotting problems, stomach or intestinal ulcers or bleeding, severe heart failure, non-dialyzed severe kidney failure. Inform your doctor before taking DROTAVERINE+NIMESULIDE if you have heart problems, or kidney or liver impairment. Do not take DROTAVERINE+NIMESULIDE if you are pregnant or breastfeeding unless prescribed by the doctor. DROTAVERINE+NIMESULIDE is not recommended for children as safety has not been established. Avoid consuming alcohol along with DROTAVERINE+NIMESULIDE as it could increase the risk of stomach bleeding. DROTAVERINE+NIMESULIDE may cause sleepiness and dizziness, so drive only if you are alert. Stop taking DROTAVERINE+NIMESULIDE and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools. Do not take any other NSAIDs for pain relief along with DROTAVERINE+NIMESULIDE unless prescribed. Concomitant use of levodopa and DROTAVERINE+NIMESULIDE should be avoided. Inform your doctor if you have a history of wheezing, chest tightness, breathlessness, sudden skin or mucosal swelling, and skin rashes after taking NSAID medication.

Drug Interactions

Drug-Drug Interaction:

DROTAVERINE+NIMESULIDE may have interaction with a blood thinner (warfarin), corticosteroids (medicines used in the treatment of inflammatory conditions), lithium which is used to treat depression, methotrexate (a medicine used for the treatment of rheumatoid arthritis), cyclosporine (a medicine used after transplantation) and levodopa (a medicine used for the central nervous system). 

Drug-Disease Interaction:

DROTAVERINE+NIMESULIDE may have interactions with severe kidney, liver, or heart failure.

Safety Advice

ALCOHOL

Avoid consumption of alcohol while taking DROTAVERINE+NIMESULIDE as it may increase the risk of stomach bleeding.

PREGNANCY

It is not recommended to use DROTAVERINE+NIMESULIDE during pregnancy. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

BREAST FEEDING

Please consult your doctor before taking DROTAVERINE+NIMESULIDE, and your doctor will decide whether DROTAVERINE+NIMESULIDE can be taken by breastfeeding mothers or not.

DRIVING

DROTAVERINE+NIMESULIDE may cause dizziness. Do not drive or operate machinery unless you are alert.

LIVER

DROTAVERINE+NIMESULIDE is not recommended in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

KIDNEY

DROTAVERINE+NIMESULIDE is not recommended in patients with severe kidney disease. Please consult your doctor if you have kidney disease or any concerns regarding this.